09/03/2017 · Let me clarify by saying that am categorized as having MCTD with unaffected internal organ Lupus. My flare ups will cause severe pain in all my muscles and joints from feet to jaw. I am usually in bed for a flare up and the recovery time is typically hours, not days. I have the chills, a sore throat, stomach sickness, and need full rest to recover. What is a flare? If you have been following me for a while you will often hear me say I am experiencing a flare. Mixed Connective Tissue Disease is a Lupus overlap condition, so Lupus and MCTD patients often share similar symptoms and experiences. How is mixed connective tissue disease treated MCTD? Treatment for MCTD must be tailored to each particular patient, depending on the organs that are affected and how severe the condition is. Some patients may need treatment only during flare-ups, while others may require constant care.